Prevention and Treatment for Perennial Ryegrass Toxicosis

Background

Perennial Ryegrass Toxicosis (PRGT) occurs in sheep (and also in cattle, deer, horses and alpaca) when they ingest a mixture of toxins present in Neotyphodium lolii infested rye grass.

Perennial ryegrass is the most commonly sown pasture grass in Australia, occupying over 6 million hectares. Approximately 90% of established perennial ryegrass plants

are infected with an endophyte fungus known as Neotyphodium lolii.

PRGT outbreaks occur across Australia and New Zealand, predominantly in summer and autumn months, during and after wet seasons. Clinical signs of PRGT include muscle tremors and “staggers”, weakness, heat stress, infertility, dehydration, collapse, and death. Currently there is no specific treatment for PRGT in the market and management efforts are constrained to pasture and seed management.

Our solution

Charles Sturt University has developed BromoTox®, a potassium bromide based treatment for PRGT which has strong product-market fit as a multi-product offering, i.e: preventative salt lick / feed additive and as a targeted treatment during outbreaks.

Our research team has established significant depth of data in support of BromoTox® including:

  • Economic impact modelling for the therapeutic management of PRGT in sheep.
  • Lab-based testing of residual tissue profiles and pharmacokinetics.
  • Delivered proof of concept.

Benefits

  • Technology readiness level 3: Analytical and experimental critical functions and proof of concept achieved, ready for formulations and packaging.
  • Formulation suited to multi-product suite.

Intellectual property

BROMOTOX Trademark in AU and NZ.

Australian Granted Patent

New Zealand Granted Patent

USA Granted Patent

Prevention and treatment of toxicoses.

Charles Sturt researchers

Recent publications

Treatment of clinical signs of perennial rye grass toxicosis in sheep (Charles Sturt University, 2017)